Histone Demethylase JHDM2A Is Involved in Male Infertility and Obesity
نویسندگان
چکیده
منابع مشابه
P-202: Reduced Expression of JMJD1A Histone Demethylase Gene in Testis Tissues of Infertile Men Referred to Royan Institute
Background: Epigenetic modifications are involved in different cellular processes through regulating chromatin dynamics. histone methylation is an important modification that can be dynamically regulated by histone methyltransferase and histone demethylase enzymes. JMJD1A (also known as JHDM2A and KDM3A) is a histone demethylase specific for H3K9me2/me1. JMJD1A is a key epigenetic regulator tha...
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a:4:{s:10:"Background";s:223:"In today's worlds of advanced technology, obesity phenomenon, more than whatever seen before, is a risk and health- threatening factor. Recent studies show that there is a relation between obesity and infertility in men.";s:19:"MaterialsAndMethods";s:178:"This paper is written with an overview of related articles published in Sciencedirect, Pubmed,SID and Iranmedex...
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BACKGROUND Some dynamic changes occurs during spermatogenesis such as histone removal and its replacement with transition nuclear protein and protamine. These proteins are required for packing and condensation of sperm chromatin. JHDM2A is a histone demethylase that directly binds to promoter regions of Tnp1 and Prm1 genes and controls their expression by removing H3K9 at their promoters. OBJ...
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Arginine methylation occurs on a number of proteins involved in a variety of cellular functions. Histone tails are known to be mono- and dimethylated on multiple arginine residues where they influence chromatin remodeling and gene expression. To date, no enzyme has been shown to reverse these regulatory modifications. We demonstrate that the Jumonji domain-containing 6 protein (JMJD6) is a JmjC...
متن کاملDemethylase activity is directed by histone acetylation.
Mammalian genomes are compartmentalized into dense inactive chromatin that is hypermethylated and active open chromatin that is hypomethylated. It is generally accepted that this bimodal pattern of methylation is established during development and is then faithfully inherited through subsequent cell divisions by a maintenance DNA methyltransferase (DNMT1). The pattern of methylation is believed...
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ژورنال
عنوان ژورنال: Journal of Andrology
سال: 2009
ISSN: 0196-3635
DOI: 10.2164/jandrol.109.008052